Pericyte mechanics and mechanobiology

ABSTRACT Pericytes are mural cells of the microvasculature, recognized by their thin processes and protruding cell body. wrap around endothelial play a central role in regulating various functions, including angiogenesis inflammation. They also serve as vascular support regulate blood flow contraction. Prior reviews have examined pericyte biological functions biochemical signaling pathways. In this Review, we focus on mechanics mechanobiology function. After an overview morphology structure pericytes, describe interactions with both basement membrane cells. We then turn our attention to biophysical considerations, contractile forces generated mechanical exerted responses these forces. Finally, discuss 2D 3D engineered vitro models for studying mechano-responsiveness underscore need more evolved that provide improved understanding function dysfunction.